Taking AJOVY

  • AJOVY is the only FDA-approved anti-CGRP that offers the flexibility of quarterly or monthly dosing options.

    Quarterly

    225 mg x 3 SQ (subcutaneous)

    Only 4 injection days per year

    or

    Monthly

    225 mg SQ (subcutaneous)

    Only 1 injection per month

  • You and your doctor can choose an administration option to help meet your treatment needs.

    In office

    By a doctor or nurse

    or

    At home*

    By yourself, or with the help of someone

    *After your doctor provides guidance on administration.

Instructions on how to use AJOVY

 

Important things to consider

Read and follow the Instructions for Use that come with your AJOVY prefilled syringe before you start using it and each time you get a refill.

 

Important:
  • AJOVY prefilled syringe is for single-time (one-time) use only. Put AJOVY in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) your used sharps disposal container in your household trash.
  • Before injecting, let AJOVY sit at room temperature for 30 minutes.
  • Keep AJOVY prefilled syringe out of the reach of small children.
  • After you remove the needle cap from AJOVY, to prevent infection, do not touch the needle.
  • Do not pull back on the plunger at any time as this can break the prefilled syringe.
  • Do not inject AJOVY in your veins (intravenously).
  • Do not re-use your AJOVY prefilled syringe as this could cause infection or injury.
  • Do not share your AJOVY prefilled syringe with another person. You may give another person an infection or get an infection from them.

You may give AJOVY yourself. If you feel uncomfortable, you should not get your first dose of AJOVY until you or your caregiver receive training from a healthcare provider on the right way to use AJOVY.

 

Storage conditions:
  • Store AJOVY in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Keep AJOVY in the carton it comes in to protect from light.
  • If needed, AJOVY may be stored at room temperature between 68°F to 77°F (20°C to 25°C) in the carton it comes in for up to 24 hours. Do not use AJOVY if it has been out of the refrigerator for 24 hours or longer. Dispose of (throw away) AJOVY in a sharps disposal container if it has been out of the refrigerator for 24 hours or longer.
  • Do not freeze. If AJOVY freezes, throw it away in a sharps disposal container.
  • Keep AJOVY out of extreme heat and direct sunlight.
  • Do not shake AJOVY.

 Read this before you inject.

 

  1. Check your prescription.

    AJOVY comes as a single-dose (1 time) prefilled syringe. Your healthcare provider will prescribe the dose that is best for you.

    • If your healthcare provider prescribes the 225 mg monthly dose for you, take 1 injection monthly, using a prefilled syringe.
    • If your healthcare provider prescribes the 675 mg every 3 months dose for you, take 3 separate injections one after another, using a different prefilled syringe for each injection. You will take these injections once every 3 months.

    Before you inject, always check the label of your single-dose prefilled syringe to make sure you have the correct medicine and the correct dose of AJOVY. If you are not sure of your dose, ask your healthcare provider.

  2. Remove the prefilled syringe from the carton.

    • You may need to use more than 1 prefilled syringe based on your prescribed dose.
    • Hold the prefilled syringe (as shown in Figure A).
    • Remove the syringe from the carton.
    • Do not shake the prefilled syringe at any time as this could affect the way the medicine works.

    Figure A Remove pre-filled syringe from carton.

  3. Gather the supplies you will need to inject AJOVY.

    Gather the following supplies (see Figure B) and the number of AJOVY 225 mg prefilled syringes you will need to give your prescribed dose:

    • If your dose is 225 mg, you will need 1 AJOVY 225 mg prefilled syringe.
      If your dose is 675 mg, you will need 3 AJOVY 225 mg prefilled syringes.
    • alcohol swabs (not supplied).
    • gauze pads or cotton balls (not supplied).
    • sharps disposal or puncture-resistant container (not supplied).

    Tell your pharmacist or healthcare provider if you do not already have a sharps or puncture-resistant container

    Figure B 

  4. Let AJOVY reach room temperature.

    • Place the supplies you have gathered on a clean, flat surface.
    • Wait for 30 minutes to allow the medicine to reach room temperature.
    • Do not leave the prefilled syringe in direct sunlight as this could damage the liquid medicine.
    • Do not warm up the AJOVY prefilled syringe using hot water, a microwave, or any other way than instructed, as this could damage the liquid medicine.
    AJOVY needs to wait 30 minutes to reach room temperature
  5. Wash your hands.

    Wash your hands with soap and water and dry well with a clean towel.

    Be careful not to touch your face or hair after washing your hands.

  6. Look closely at your AJOVY prefilled syringe.

    Note: You may see air bubbles in the prefilled syringe. This is normal. Do not remove the air bubbles from the prefilled syringe before giving your injection. Injecting AJOVY with these air bubbles will not harm you.

    • Check that the liquid medicine in the prefilled syringe is clear and colorless to slightly yellow before you give your injection. (See Figure C). If the liquid has any particles in it, or is discolored, cloudy or frozen, do not use the prefilled syringe. Call your healthcare provider or pharmacist.
    • Do not use the prefilled syringe if it has any visible damage, such as cracks or leaks. See disposal instructions in Step 12.
    • Check that AJOVY appears on the prefilled syringe. Do not use if you have been given the wrong medicine.
    • Check the expiration date printed on the prefilled syringe label.
    • Do not use if you have been given the wrong medicine.
    • Do not use the prefilled syringe if the expiration date has passed.

    The above checks are all important to make sure the medicine is safe to use.

    Figure C 

  7. Choose your injection area.

    Choose an injection area from the following areas (see Figure D):

    • your stomach area (abdomen), avoid about 2 inches around the belly button
    • the front of your thighs, an area that is at least 2 inches above the knee and 2 inches below the groin
    • the back of your upper arms, in the fleshy areas of the upper back portion

    Figure D Stomach, thighs or back of upper arm are areas that AJOVY can be injected to

    Note: There are some injection areas on your body that are hard to reach (like the back of your arm). You may need help from someone who has been instructed on how to give your injection if you cannot reach certain injection areas.

  8. Clean your injection area.

    • Clean the chosen injection area using a new alcohol swab.
    • Wait 10 seconds to allow the skin to dry before injecting.
    • Do not inject AJOVY into an area that is tender, red, bruised, calloused,
      tattooed, hard, or that has scars or stretch marks.
    • Do not inject AJOVY in the same injection site that you inject other medicine.
    • If you want to use the same body site for the three seperate injections needed for the 675 mg dose, make sure the second and third injections are not at the same spot you used for the other injections.
  9. Remove needle cap and do not replace.

    • Pick up the body of the prefilled syringe with 1 hand.
    • Pull the needle cap straight off with your other hand (see Figure E). Do not twist.
    • Throw away the needle cap right away.
    • Do not put the needle cap back on the prefilled syringe, to avoid injury and infection.

    Figure E Remove cap of AJOVY pre-filled syringe before use

  10. Give your injection following the 4 steps below.

    1. Use your free hand to gently pinch up at least 1 inch of the skin that you have cleaned.

      Gently pinch skin at least one pinch
    2. Insert the needle into the pinched skin at a 45 to 90 degree angle.

      Insert AJOVY pre-filled syringe into pinched skin
    3. When the needle is all the way into your skin, use your thumb to push the plunger.

      Use thumb to push plunger of AJOVY pre-filled syringe
    4. Push the plunger slowly all the way down as far as it will go to inject all of the medicine.

      Slowly push plunger of AJOVY pre-filled syringe all the way down
  11. Remove the needle from your skin.

    • After you have injected all of the medicine, pull the needle straight out (see Figure F).
    • Do not recap the needle at any time, to avoid injury and infection.

    Figure F Remove AJOVY pre-filled syringe in an upward motion

  12. Apply pressure at the injection site.

    • Use a clean, dry cotton ball or gauze to gently press on the injection site for a few seconds.
    • Do not rub the injection site.
    • Do not re-use the prefilled syringe.
  13. Dispose of your prefilled syringe right away.

    • Put your used prefilled syringes, needles and sharps in a FDA-cleared sharps disposal container right away after use.
    • Do not throw away (dispose of) loose needles, syringes, or prefilled syringes in your household trash. Do not recycle your used sharps disposal container.
    • If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:
      • made of a heavy-duty plastic,
      • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
      • upright and stable during use,
      • leak-resistant, and
      • properly labeled to warn of hazardous waste inside the container.
    • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
    • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.

      Injection Complete

Storage and Handling

  • Store AJOVY in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Keep AJOVY in the carton it comes in to protect from light.
  • If needed, AJOVY may be stored at room temperature between 68°F to 77°F (20°C to 25°C) in the carton it comes in for up to 24 hours. Do not use AJOVY if it has been out of the refrigerator for 24 hours or longer. Dispose of (throw away) AJOVY in a sharps disposal container if it has been out of the refrigerator for 24 hours or longer.
  • Do not freeze. If AJOVY freezes, throw it away in a sharps disposal container.
  • Keep AJOVY out of extreme heat and direct sunlight.
  • Do not shake AJOVY. 

 

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