Autoinjector migraine injection instructions

How to use the AJOVY Autoinjector

Watch the video below or scroll down for step-by-step instructions. Follow these directions whether you take AJOVY quarterly or monthly.

AJOVY comes in an easy-to-use autoinjector.* You can use the autoinjector by yourself at home, or have it administered by your healthcare provider in their office. AJOVY also comes in a prefilled syringe. For instructions on how to use the prefilled syringe, click here.

*Two human factor studies assessed evaluators’ ability to complete critical tasks in order to demonstrate use of the AJOVY Autoinjector in simulated-use sessions. When asked “Was the autoinjector easy to use?”, 97% in study 1 (N=30) and 98% in study 2 (N=47) answered “Yes”.

Step-by-step autoinjector instructions

To prepare for your injection, take your autoinjector out of the refrigerator. Make sure to wait 30 minutes until it reaches room temperature. Now you’re ready to follow the steps below.

Step 1:

Uncap the autoinjector

With one hand, firmly pull the cap straight off the autoinjector (don’t twist) and throw the cap away immediately.

AJOVY Autoinjector instructions step 1

Step 2:

Place at a 90o angle

Place the autoinjector at a 90° angle against your skin at your chosen injection site.

AJOVY Autoinjector instructions step 2

Step 3:

Press down and hold autoinjector until 10 seconds after second click

Press down on the autoinjector. You will hear a click. This means the injection has started and you should see the blue plunger move down. You will hear a second click. Remove autoinjector 10 seconds after.

AJOVY Autoinjector instructions step 3

For more detailed steps on using the AJOVY Autoinjector, read the full Instructions for Use.

Download full instructions for taking AJOVY Autoinjector Read full instructions for use

Important things to know before injecting:

  • Before injecting, let AJOVY sit at room temperature for 30 minutes. Do not warm up using a heat source such as hot water or a microwave.
  • Keep AJOVY Autoinjector out of the reach of small children.
  • After you remove the needle cap, to prevent infection, do not touch the needle.
  • DO NOT inject AJOVY in your veins (intravenously).
  • DO NOT reuse your AJOVY Autoinjector as this could cause infection or injury.
  • DO NOT share your AJOVY Autoinjector with another person. You may give another person an infection or get an infection from them.
  • You may give AJOVY yourself. If you feel uncomfortable, you should not get your first dose of AJOVY until you or your caregiver receive training from a healthcare provider on the right way to use AJOVY.

How to Dispose Used Sharps: DO’s and DON’Ts

The AJOVY Autoinjector is for single-time (one-time) use only. After use, be sure to follow these rules: DO put the autoinjector into an FDA-approved sharps disposal container right away. DON'T ever throw away the sharps disposal container, or any loose needles and syringes, in your household trash. For a more complete list of "DO's and DON'Ts" and to learn more, download our Sharps Disposal Brochure below.

Download the sharps disposal brochure Download Sharps Disposal Brochure 
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How to store and handle the AJOVY Autoinjector

  • Make sure to keep AJOVY in the refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze.
  • Keep AJOVY in the carton it comes in to protect from light.
  • If necessary, AJOVY may be kept in the original carton at room temperature up to 30°C (86°F) for a maximum of 7 days. After removal from the refrigerator, AJOVY must be used within 7 days or discarded. Once stored at room temperature, do not place back in the refrigerator.
  • DO NOT freeze. If AJOVY freezes, throw it away in a sharps disposal container.
  • Keep AJOVY out of extreme heat and direct sunlight.
  • DO NOT shake AJOVY.

Download and read the full storage and handling instructions before you start taking AJOVY.

Download the storage and handling instructions Download full Storage and Handling instructions